How Psoriatic Arthritis Works

The cause of psoriasis is not fully understood, thus it is also difficult to explain how and why it runs its specific course, although genetic factors are the most prominent and perhaps likely initial explanation.

Upon microscopic examination of tissue samples, it can be seen, however, that changes in skin due to psoriasis and changes in the synovium (joints) from psoriatic arthritis are remarkably similar, and analysis at the cellular level suggest that the immune system plays a strong role in the spread of the disease from skin to joint.

Other studies suggest that diverse environmental factors, such as infection, physical trauma and microbial antigens could activate the PSA mechanisms.